drove inflammatory changes varies, are studied. Some alopecias known, but current type in both men and women is androgenic, that is induced by the androgenic hormone (AH) striking the scalp hair follicles. AH is important in the physiology of skin, promoting the growth of beard and body hair alive. The growth of scalp hair also depends on AH, but only in early life away. It’s not even why AH, with increasing age, changes to promote growth of scalp hair loss are explained to, known as a conditioning induce androgenic effluvium (AE) and alopecia (AGA),. In hirsutism and acne vulgaris was abundant HUIDAH shocked to be the major factor in these complex syndromes.

The AH may be her only on the androgenic receptor (AR), a cellular protein transcription factor measures which interact with a specific area of DNA interacts. Thus, both testosterone and its stronger analogue, 5-alpha-dihydrotestosterone (DHT), must go to the AR in the hair follicles to bind her to take.

Antiandrogens (AA) is systemically administered drugs that inhibit the AH that binds to AR. Originally developed to treat prostate cancer, these compounds, since they impede AR systemically significant side effects, including loss of libido and risks of male sexual function. These drugs are not used in men for the AE or AGA treatment to anyone, even locally, since it is well resorbed by the skin and is stable in vivo. Local steroidal AA as cyproterone acetate, chlormadinone acetate and spironolactone was not successful, presumably because of poor absorption into the skin, some have a skin irritation potential.

AA administered systemically were proposed for the treatment of women suffering from AE and AGA (Ref. # 1), but concerns for side effects calls for clinical studies. It is generally, at least in men, prolonged AR blockade leads to AR change and knew that the mutant receptor reaches the capacity of other substances such as various steroidal metabolites and even progestogens and estrogen, insulin-like growth factor, epidermal growth factor and keratinocyte growth factor and neuroendocrine transmitters such as serotonin is activated. It has also been shown that the AR gene increased the AR blockade. It is therefore apparent that the treatment of hair loss in women by blocking AR with systemic AA is not ideal and that the men would be acceptable to everyone are not.

Currently available for treatment of AE and AGA are local Minoxidil and its analog, including Aminexil and oral finasteride (Ref. # 2). Minoxidil, a medicine for high blood pressure medication, avoid accompanying hair loss and size, promotes regrowth, but only in the top scalp, the activity is tentatively by activation of the prostaglandin endo-peroxide synthase-1, increased local blood flow, including others, suppression of bacterial infection and / or a change in the AH metabolism in the dermal papilla explained. (Refs. 3,4,5).

Took finasteride orally daily and suppresses conversion of testosterone into dihydrotestosterone (DHT) and thus does the AH activity in the scalp down. The studies indicate about half of the men reached improvements in the low to mid-scalp prior to moderate and approximately one-half, was arrested the effluvium. Side effects include decreased libido and erectile function after drug withdrawal disappear. (Ref. # 6) No studies are available to prove whether such a long-term systemic manipulation of hormonal balance is compensated.

Clearly, a locally active antiandrogen that instead of impeding HUIDAR suppressed, and while not absorbable by the body skin irritant, are useful in the treatment of AH dependent skin mart.

We designed and proposed a number of novel anti-androgens and found that only together, rather than hinder, suppressed the AR in a concentration-dependent fashion and control.

Some of these compounds displayed extremely low or no systemic bioavailability of oral and / or local application. The group homes with the best overall properties of local active suppression of huidandrogen receptors proved BP-766 (Fluridil) tool, given the rapidly degradable in two components of high systemic and local tolerance without antiandrogenic activity. It therefore provides a novel concept in health and cosmetic treatment androgenic effluvium and alopecia novice as well as other skin conditions such as hirsutism of the abundance of the skin depends on male hormones in both men and women.

Some alopecias known, but current type in both men and women is androgenic, that is induced by the androgenic hormone (AH) striking the scalp hair follicles. AH is important in the physiology of skin, promoting the growth of beard and body hair alive.

The growth of scalp hair also depends on AH, but only in early life away. It’s not even why AH, with increasing age, changes to promote growth of scalp hair loss are explained to, known as a conditioning induce androgenic effluvium (AE) and alopecia (AGA). In hirsutism and acne vulgaris was abundant HUIDAH shocked to be the major factor in these complex syndromes.

The AH may be her only on the androgenic receptor (AR), a cellular protein transcription factors which interact to affect a specific region of DNA interacts. Thus, both testosterone and its stronger analogue, 5-alpha-dihydrotestosterone (DHT), to the AR in the hair follicles to bind her to take.

Antiandrogens (AA) is systemically administered drugs that inhibit the AH that binds to AR. Originally developed to treat prostate cancer, these compounds, since they impede AR systemically significant side effects, including loss of libido and risks of male sexual function. These drugs are not used in men for the AE or AGA treatment to anyone, even locally, since it is well resorbed by the skin and is stable in vivo. Local steroidal AA as cyproterone acetate, chlormadinone acetate and spironolactone was not successful, presumably because of poor absorption into the skin, some have a skin irritation potential.

AA administered systemically were proposed for the treatment of women suffering from AE and AGA (Ref. # 1), but concerns for side effects calls for clinical studies. It is generally, at least in men, prolonged AR blockade leads to AR change and knew that the mutant receptor reaches the capacity of other substances such as various steroidal metabolites and even progestogens and estrogen, insulin-like growth factor, epidermal growth factor and keratinocyte growth factor and neuroendocrine transmitters such as serotonin is activated. It has also been shown that the AR gene increased the AR blockade. It is therefore apparent that the treatment of hair loss in women by blocking AR with systemic AA is not ideal and that the men would be acceptable to everyone are not.

Currently available for treatment of AE and AGA are local Minoxidil and its analog, including Aminexil and oral finasteride (Ref. # 2). Minoxidil, a medicine for high blood pressure medication, avoid accompanying hair loss and size, promotes regrowth, but only in the top scalp, the activity is tentatively by activation of the prostaglandin endo-peroxide synthase-1, increased local blood flow, including others, suppression of bacterial infection and / or a change in the AH metabolism in the dermal papilla explained. (Refs. 3,4,5).

Took finasteride orally daily and suppresses conversion of testosterone into dihydrotestosterone (DHT) and thus does the AH activity in the scalp down. The studies indicate about half of the men achieved little to improve the previous mid-to moderate scalp and in approximately one-half, was arrested the effluvium. Side effects include decreased libido and erectile function after drug withdrawal disappear. (Ref. # 6) No studies are available to prove whether such a long-term systemic manipulation of hormonal balance is compensated.

Clearly, a locally active antiandrogen that instead of impeding HUIDAR suppressed, and while not absorbable by the body skin irritant, are useful in the treatment of AH dependent skin mart.

We designed and proposed a number of novel anti-androgens and found that only together, rather than hinder, suppressed the AR in a concentration-dependent fashion and control. (Ref. # 7) Some of these compounds displayed extremely low or no systemic bioavailability of oral and / or local application. The group homes with the best overall properties of local active suppression of huidandrogen receptors proved BP-766 (Fluridil) tool, given the rapidly degradable in two components of high systemic and local tolerance without antiandrogenic activity. It therefore provides a novel concept in health and cosmetic treatment androgenic effluvium and alopecia novice as well as other skin conditions such as hirsutism of the abundance of the skin depends on male hormones in both men and women.